RICHMOND--Virginia State Police had a busy Wednesday as snow, ice and heavy rains crossed the state.

Two people were killed in the icy conditions. According to Va. State Police, a 14-year-old girl was killed in Campbell County when a vehicle she was riding in ran off the road and hit a tree. Two other teens were injured.

A 35-year-old Covington woman was killed in Botetourt County when she lost control of her vehicle on U.S. 220 in Eagle Rock. The vehicle crossed the center line and was hit by another vehicle.

There were many crashes in the northern, western and central parts of Virginia.

In the Hampton Roads area, which experienced mostly heavy rain, there were 41 crashes, 28 disabled vehicles and 163 total calls for service.

In contrast, the area including Fredericksburg and Harrisonburg had the most crashes with 183 and 253 calls for service.

The State police is reminding motorists to make safety a priority, especially as temperatures drop in the overnight hours. Ice could be a threat to drivers particularly in the higher elevations.

Police are reminding those who must travel to follow these safety tips:

-Drive for conditions. Slow down your speed when possible.
-Make sure your headlights, taillights and windshield wipers are in working order. Brush snow off your taillights, headlights and windows to increase visibility for yourself and other drivers.
-Increase driving distances. Give yourself more space between you and the vehicle in front of you...if you should lose control or the vehicle in front of you loses control, then you will need that extra driving space to safely react and stop.
-Always wear your seat belt.
-Give yourself extra drive time. Bring along your cell phone charger and be prepared for winter travel. -For those traveling in the regions experiencing mainly rain, remember that state law does require vehicles to have their headlights on when windshield wipers are activated. Also, beware of standing water as the heavy rains are causing water to pool on the roadways. Never go through high water.

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